Characterization and Biological Activities of Ethanol Extract of Justicia carnea
Keywords:
Active metabolites, antimicrobial, antioxidant, Justicia carneaAbstract
For a long time, the blood tonic and other therapeutic qualities of the medicinal herb Justicia carnea have been utilized in Nigeria. The purpose of this research is to learn more about the biological activity and phytochemical profile of the Justicia carnea ethanol extract. The phytochemicals in Justicia carnea were identified using GC-MS and Fourier transform infrared spectroscopy. An 100% ethanol extraction was performed on the powdered sample, and the resulting extract was concentrated using a rotary evaporator. Among the many potential medical applications of the few active metabolites identified by the study are those for lowering inflammation, fighting diabetes, regulating the immune system, and even curing malaria. Extract from Justicia carnea was most effective against Salmonella typhi, an infectious disease, with a MIC of 0.001 mg/L. It is thought to have the most promising antioxidant properties at a concentration of 0.50 g/ml, inhibiting peroxide and superoxide radicals with an inhibition diameter of 70.41 and 74.57 mm, respectively. The therapeutic properties of Justicia carnea extract are being investigated by the medical communityDownloads
References
Anarado, E. C., Ajiwe, I. E. V., Anarado, J. O. C., Obumselu, F. O., Umedum, L. N., & Okafor, E. S. (2021). The phytochemistry, ethnomedicinal and pharmacological uses of Justicia carnea Lindl used in traditional medicine in Nigeria: A review. South Asian Research Journal of Natural Products, 4(4), 85–93.
Alamgir, A. N. M. (2018). Secondary metabolites: Secondary metabolic products consisting of C and H; C, H, and O; N, S, and P elements; and O/N heterocycles. In Therapeutic Use of Medicinal Plants and Their Extracts (Vol. 2, pp. 165–309).
Andrew, A. C., Nwaoguikpe, R. N., Ujowundu, C. O., & Ujowundu, F. N. (2024). Biochemical analysis of Justicia carnea leaves used as a hematinic. GSC Biological and Pharmaceutical Sciences, 26(2), 105–114.
Ani, O. N., Udedi, S. C., Akpata, E. I., Ezeigwe, O. C., Oguazu, C. E., Onyishi, C. K., & Nwakaudu, E. N. (2020). Effects of ethanol leaf extract of Justicia carnea on biochemical indices of alloxan-induced diabetic rats. IOSR Journal of Biotechnology and Biochemistry, 6(2), 39–46.
Banerjee, M., Khursheed, R., Yadav, A. K., Singh, S. K., Gulati, M., Pandey, D. K., & Pandey, N. K. (2020). A systematic review on synthetic drugs and phytopharmaceuticals used to manage diabetes. Current Diabetes Reviews, 16(4), 340–356.
Corrêa, G. M., & Alcântara, A. F. D. C. (2012). Chemical constituents and biological activities of species of Justicia: A review. Revista Brasileira de Farmacognosia, 22(1), 220–238.
Cotoraci, C., Ciceu, A., Sasu, A., & Hermenean, A. (2021). Natural antioxidants in anemia treatment. International Journal of Molecular Sciences, 22(4), 1883.
Donlawson, C., Nweneka, D. O., Orie, K. J., & Okah, R. (2020). Synthesis and bioactivity of 1-((2-carbamoylguanidino)(furan-2-ylmethyl) urea. American Journal of Analytical Chemistry, 11(7), 280–288.
Imohiosen, O. (2023). Phytochemical analysis on aqueous leaf extract of Justicia carnea (Acanthaceae) and its antibacterial activity on some isolated bacteria. American Journal of Food Science and Technology, 2(1), 16–20.
Kitadi, J. M., Lengbiye, E. M., Gbolo, B. Z., Inkoto, C. L., Muanyishay, C. L., Lufuluabo, G. L., & Mpiana, P. T. (2019). Justicia secunda Vahl species: Phytochemistry, pharmacology and future directions: A mini-review. Discovery Phytomedicine, 6(4), 157–171.
Kpoviessi, D. S., Gbaguidi, F., Gbenou, J., Accrombessi, G., Haddad, M., Moudachirou, M., & Quetin-Leclercq, J. (2006). Allelopathic effects on cowpea (Vigna unguiculata) and cytotoxic activities of sterols and triterpenes isolated from Justicia anselliana. Journal of Natural Substances, 1, 12–19.
Manokari, M., Latha, R., Priyadharshini, S., Cokul, R. M., Beniwal, P., Manjunatha, R. Y., & Shekhawat, M. S. (2019). A comprehensive review on a less explored medicinally important plant Justicia betonica L. World Scientific News, 131, 110–122.
Martins, C. D. M., Nascimento, E. A., de Morais, S. A., de Oliveira, A., Chang, R., Cunha, L., & de Aquino, F. J. (2015). Chemical constituents and evaluation of antimicrobial and cytotoxic activities of Kielmeyera coriacea essential oils. Evidence-Based Complementary and Alternative Medicine, 2015.
Minaopunye, O. O. B., Chimezie, O. H., & Uchechi, O. N. C. (2021). Biochemical evaluation of chloramphenicol-induced lymphoma and ameliorative potentials of Justicia carnea and Cnidoscolus aconitifolius in male Wistar rats. GSC Advanced Research and Reviews, 9(1), 128–136.
Nna, P. J., Legborsi, J., & Orie, K. J. (2020). Comparative study on the phytoconstituents and antimicrobial analysis of Jatropha curcas leaf and stem bark. Direct Research Journal of Chemistry and Material Science, 7(3), 37–43.
Okocha, B. I., Orie, K. J., Duru, R. U., & Ngochindo, R. L. (2023). Analysis of the active metabolites of ethanol and ethyl acetate extract of Justicia carnea. African Journal of Biomedical Research, 26(1), 109–117.
Oloruntola, O. D., Ayodele, S. O., Adeyeye, S. A., Fasuhami, O. S., Osowe, C. O., & Ganiyu, T. O. (2022). Proximate composition, phytochemical profile, antioxidant, antidiabetic and anti-inflammatory properties of Justicia carnea leaf powder. Black Sea Journal of Agriculture, 5(4), 415–423.
Orie, K. J., & Okocha, B. I. (2024). In vitro antimicrobial and free radical scavenging activity of metal ion complexes. African Journal of Biomedical Research, 27(2), 349–357.
Orie, K. J., Duru, R. U., & Ngochindo, R. I. (2021). Metal complexes of heterocyclic sulphonamide: Synthesis, characterization and biological activity. Science Journal of Analytical Chemistry, 9(4), 104–109.
Salehi, B., Venditti, A., Sharifi-Rad, M., Kręgiel, D., Sharifi-Rad, J., Durazzo, A., & Martins, N. (2019). The therapeutic potential of apigenin. International Journal of Molecular Sciences, 20(6), 1305.
Scarim, C. B., Chelucci, R. C., Dos Santos, J. L., & Chin, C. M. (2020). The use of sulfonamide derivatives in the treatment of trypanosomatid parasites. Medicinal Chemistry, 16(1), 24–38.
Silva, L. J., Lino, C. M., Meisel, L. M., & Pena, A. (2012). SSRIs in the aquatic environment: An ecopharmacovigilance approach. Science of the Total Environment, 437, 185–195.
Ukpabi-Ugo, J. C., Uhuo, E. N., Ugwu, O. C., & Chukwuma, E. W. (2023). Evaluation of subacute toxicity of methanol extract of Justicia carnea leaves in Wistar albino rats. Animal Research International, 20(1), 4862–4875.
Vyas, R., Kesari, K. K., Lukac, N., Slama, P., Roychoudhury, S., & Sisodia, R. (2023). Radical scavenging activity of Chlorophytum borivilianum root extract and its protective role in sperm integrity. Frontiers in Cell and Developmental Biology, 11, 1064574.
Xia, S., Lin, H., Zhu, P., Wang, P., Liao, S., Chen, S., & Fan, G. (2020). Inhibitory effects of Litsea cubeba oil on Aspergillus flavus. Journal of Food Quality, 2020, 8843251.
Yin, Z., & Wang, H. (2017). Role of atmospheric circulations in haze pollution. Atmospheric Chemistry and Physics, 17(18), 11673–11681.
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